Role of Microrna 135 (MIR-135) in the development of hippocampal neurons / Marcelo Andrés Díaz Bustamante.

Por:

Díaz Bustamante, Marcelo Andrés [author.]

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Tipo de material: Texto

TextoIdioma: Español Editor: Valparaíso, Chile : Universidad de Valparaíso, 2010Descripción: 88 hojas : ilustracionesTema(s):

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Nota de disertación: Doctor en Ciencias con Mención en Neurociencia. Resumen: MicroRNAs (miRNAs) are small non-coding RNAs (~21-25 nucleotides) that post-transcriptionally regulate gene expression. By interacting with specific binding sites in their mRNA targets, miRNAs can decrease translation efficiency or trigger mRNA degradation. miRNAs have been implicated in a variety of biological functions. It remains largely unclear to what extent microRNAs regulate protein expression during brain development and how this influences brain function. miRNA 135 (miR-135) appears as a very attractive candidate that may be important for neuronal function. Besides being enriches in the brain, many of its predicted targets are related with synaptic function and neuronal development.

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Tipo de ítem	Biblioteca actual	Colección	Signatura topográfica	Estado	Fecha de vencimiento	Código de barras	Reserva de ítems
Tesis Postgrado	Ciencias Tesis	Tesis	M D542r 2010	Disponible		00145313

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Doctor en Ciencias con Mención en Neurociencia.

MicroRNAs (miRNAs) are small non-coding RNAs (~21-25 nucleotides) that post-transcriptionally regulate gene expression. By interacting with specific binding sites in their mRNA targets, miRNAs can decrease translation efficiency or trigger mRNA degradation. miRNAs have been implicated in a variety of biological functions. It remains largely unclear to what extent microRNAs regulate protein expression during brain development and how this influences brain function. miRNA 135 (miR-135) appears as a very attractive candidate that may be important for neuronal function. Besides being enriches in the brain, many of its predicted targets are related with synaptic function and neuronal development.