Vista normal Vista MARC Vista ISBD

Study of the role of CCAP neurons of the ecdysial behavorial sequence through mathematical and computational methods / Miguel Piñeiro Feick.

Por:

Piñeiro Feick, Miguel [author.]

Colaborador(es):

Tipo de material: Texto

TextoEditor: Valparaíso : Universidad de Valparaíso, 2018Descripción: 67 hojasTipo de contenido:

text

Tipo de medio:

unmediated

Tipo de soporte:

volume

Tema(s):

Otra clasificación:

Nota de disertación: Doctor en Ciencias mención en Neurociencias. Resumen: Animal behavior arises from the interplay between neural, biomechanical and environmental dynamics. Neuromodulators, such as neuropeptides can regulate and reconfigure neural circuits to alter their output, affecting in this way animal behavior. How neuromodulators act on neural circuits to produce distinct behaviors is still poorly understood. Here I studied the peptidergic circuits that orchestrates the ecdysis behavioral sequence in Drosophila. This behavioral sequence has three phases: pre-ecdysis, ecdysis and post-ecdysis. The sequence is initiated by the release of ecdysis-triggering hormone (ETH) which activates multiple neuronal targets of which crustacean cardioactive peptide (CCAP) neurons have been identified as key for the successful execution of the behavioral sequence. How CCAP neurons regulate the behavioral sequence is still not clear, but studies of Manduca have showed that CCAP can initiate the ecdysial motor activity. I used calcium imaging data (from CCAP neurons only, and from CCAP neurons together with motoneurons), behavioral data from pupal ecdysis, and mathematical and computational approaches to study the dynamics and functional connectivity between CCAP neurons and motoneurons, and how they relate to the behavior. I found that CCAP neurons tightly regulate the motoneuronal activity during the ecdysis and post-ecdysis phases, consistent with the recent identification of CCAP targets. The behavioral analysis showed that while the three major phases of the ecdysis sequence can be detected in the motoneuronal recordings, motoneurons have major differences in the timing and regularity of their activity. Moreover, I found that the post-ecdysis phase has two subphases which appear to be absent in the motoneuro nal recordings. These results give us new insights into the peptidergic regulation of motor programs and behaviors.

Existencias ( 1 )
Notas de título ( 2 )

Existencias
Tipo de ítem	Biblioteca actual	Colección	Signatura topográfica	Estado	Fecha de vencimiento	Código de barras	Reserva de ítems
Tesis Postgrado	Ciencias Tesis	Tesis	M P661s 2018	Disponible		00413958

Total de reservas: 0

Doctor en Ciencias mención en Neurociencias.

Animal behavior arises from the interplay between neural, biomechanical and environmental dynamics. Neuromodulators, such as neuropeptides can regulate and reconfigure neural circuits to alter their output, affecting in this way animal behavior. How neuromodulators act on neural circuits to produce distinct behaviors is still poorly understood. Here I studied the peptidergic circuits that orchestrates the ecdysis behavioral sequence in Drosophila. This behavioral sequence has three phases: pre-ecdysis, ecdysis and post-ecdysis. The sequence is initiated by the release of ecdysis-triggering hormone (ETH) which activates multiple neuronal targets of which crustacean cardioactive peptide (CCAP) neurons have been identified as key for the successful execution of the behavioral sequence. How CCAP neurons regulate the behavioral sequence is still not clear, but studies of Manduca have showed that CCAP can initiate the ecdysial motor activity. I used calcium imaging data (from CCAP neurons only, and from CCAP neurons together with motoneurons), behavioral data from pupal ecdysis, and mathematical and computational approaches to study the dynamics and functional connectivity between CCAP neurons and motoneurons, and how they relate to the behavior. I found that CCAP neurons tightly regulate the motoneuronal activity during the ecdysis and post-ecdysis phases, consistent with the recent identification of CCAP targets. The behavioral analysis showed that while the three major phases of the ecdysis sequence can be detected in the motoneuronal recordings, motoneurons have major differences in the timing and regularity of their activity. Moreover, I found that the post-ecdysis phase has two subphases which appear to be absent in the motoneuro nal recordings. These results give us new insights into the peptidergic regulation of motor programs and behaviors.