Díaz Bustamante, Marcelo Andrés, <br/><br/>
Role of Microrna 135 (MIR-135) in the development of hippocampal neurons / 
Marcelo Andrés Díaz Bustamante. 
 - 88 hojas :  ilustraciones. 
<br/><br/>Doctor en Ciencias con Mención en Neurociencia. 
<br/><br/> MicroRNAs (miRNAs) are small non-coding RNAs (~21-25 nucleotides) that post-transcriptionally regulate gene expression. By interacting with specific binding sites in their mRNA targets, miRNAs can decrease translation efficiency or trigger mRNA degradation. miRNAs have been implicated in a variety of biological functions. It remains largely unclear to what extent microRNAs regulate protein expression during brain development and how this influences brain function. miRNA 135 (miR-135) appears as a very attractive candidate that may be important for neuronal function. Besides being enriches in the brain, many of its predicted targets are related with synaptic function and neuronal development. 
<br/><br/><label>Subjects--Topical Terms: </label><br/>ADN.<br/>CEREBRO.<br/>EXPRESION GENICA.