TY  - BOOK
AU  - Díaz Bustamante, Marcelo Andrés,
AU  - Li,Zheng
AU  - Aliaga Rojas,Esteban
AU  - Ewer Lothian,John
AU  - Holmgren,Miguel
AU  - Sierralta,Jimena
AU  - Whitlock Leaning,Kathleen
ED  - Universidad de Valparaíso.
TI  - Role of Microrna 135 (MIR-135) in the development of hippocampal neurons
PY  - 2010///
CY  - Valparaíso, Chile
PB  - Universidad de Valparaíso
KW  - ADN
KW  - CEREBRO
KW  - EXPRESION GENICA
N1  - Doctor en Ciencias con Mención en Neurociencia
N2  - MicroRNAs (miRNAs) are small non-coding RNAs (~21-25 nucleotides) that post-transcriptionally regulate gene expression. By interacting with specific binding sites in their mRNA targets, miRNAs can decrease translation efficiency or trigger mRNA degradation. miRNAs have been implicated in a variety of biological functions. It remains largely unclear to what extent microRNAs regulate protein expression during brain development and how this influences brain function. miRNA 135 (miR-135) appears as a very attractive candidate that may be important for neuronal function. Besides being enriches in the brain, many of its predicted targets are related with synaptic function and neuronal development
ER  -