000			02180nam a2200373 i 4500
001			500000185
003			UVAL
005			20240507115302.0
007			ta
008			100615s esp g 000 0 spa d
040			_aDIBRA _bspa _cUVAL _erda
041	0		_aspa
084			_aM
100	0		_aDíaz Bustamante, Marcelo Andrés, _eauthor.
245	0	0	_aRole of Microrna 135 (MIR-135) in the development of hippocampal neurons / _cMarcelo Andrés Díaz Bustamante.
264		1	_aValparaíso, Chile : _bUniversidad de Valparaíso, _c2010.
300			_a88 hojas : _bilustraciones.
502			_aDoctor en Ciencias con Mención en Neurociencia.
520			_aMicroRNAs (miRNAs) are small non-coding RNAs (~21-25 nucleotides) that post-transcriptionally regulate gene expression. By interacting with specific binding sites in their mRNA targets, miRNAs can decrease translation efficiency or trigger mRNA degradation. miRNAs have been implicated in a variety of biological functions. It remains largely unclear to what extent microRNAs regulate protein expression during brain development and how this influences brain function. miRNA 135 (miR-135) appears as a very attractive candidate that may be important for neuronal function. Besides being enriches in the brain, many of its predicted targets are related with synaptic function and neuronal development.
650		0	_aADN.
650		0	_aCEREBRO.
650		0	_aEXPRESION GENICA.
700	1		_aLi, Zheng, _eDirectora de Tesis _9131189.
700	1		_aAliaga Rojas, Esteban, _eComisión de evaluación de tesis _9131186.
700	1		_aEwer Lothian, John, _eComisión de evaluación de tesis _9131187.
700	1		_aHolmgren, Miguel, _eComisión de evaluación de tesis _9131188.
700	1		_aSierralta, Jimena, _eComisión de evaluación de tesis _9131190.
700	1		_aWhitlock Leaning, Kathleen, _eComisión de evaluación de tesis _9207886.
710	2		_aUniversidad de Valparaíso. _bFacultad de Ciencias. _bPrograma de Doctorado en Ciencias con Mención en Neurociencia _9231296.
942			_c5 _2ddc
999			_c90459 _d90459